JPC SYSTEMIC PATHOLOGY

INTEGUMENTARY SYSTEM

October 2013

I-M31

 

Signalment (JPC #2780588):  Cat, breed and age unspecified 

HISTORY:  This cat had weight loss and areas of alopecia around all mucocutaneous junctions, the legs, and axillary regions for 4 weeks.  The cat also had multiple masses in the liver.

HISTOPATHOLOGIC DESCRIPTION:  Haired skin:  There is a diffuse paucity of hair follicles and hair shafts.  Remaining hair follicles are small (atrophy), located primarily in the superficial dermis and surrounded by fibroblasts and smudgy collagen (fibrosis).  There is attenuation of the external root sheath epithelium and a lack of internal root sheath epithelium (telogenization) and there are occasional small basophilic clusters of secondary hair germ at the base of attenuated follicles.  Multifocally there is rare atrophy of sebaceous glands.  The stratum corneum is thinned and parakeratotic, and there is mild epidermal hyperplasia with acanthosis, rete ridge formation, spongiosis and intracellular edema (hydropic degeneration). 

MORPHOLOGIC DIAGNOSIS:   Haired skin:  Follicular atrophy, diffuse, severe, with stratum corneum thinning, parakeratosis, and mild epidermal hyperplasia, breed unspecified, feline

CONDITION:  Paraneoplastic alopecia

SYNONYMS:  Pancreatic paraneoplastic alopecia

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

DIFFERENTIAL DIAGNOSIS:

COMPARATIVE PATHOLOGY:

Principle cutaneous paraneoplastic syndromes

REFERENCES:

  1. Caporali, C., Albanese, F., Binanti, D., and Abramo, F. Two cases of feline paraneoplastic alopecia associated with a neuroendocrine pancreatic neoplasia and a hepatosplenic plasma cell tumor.  Vet Derm. 2016; doi:10.1111/vde.12375 [Epub ahead of print].
  2. Finley MR, Rebhun WC, Dee A, Langsetmo I. Paraneoplastic pruritus and alopecia in a horse with diffuse lymphoma. J Am Vet Med Assoc. 1998; 213:102-104.
  3. Gross TL, Ihrke PJ, Walder EJ, Affolter VK. Skin Diseases of the Dog and Cat. Ames, IA: Blackwell Science; 2006:487-490, 498-501, 513-515.
  4. Hargis AM, Ginn PE: The integument. In: McGavin MG, Zachary JF, eds. Pathologic Basis of Veterinary Disease. 5th ed. St. Louis, MO; Elsevier: 1077.
  5. Marconato L, Albanese F, Viacava P, Marchetti V, Abramo F. Paraneoplastic alopecia associated with hepatocellular carcinoma in a cat. Vet Dermatol. 2007; 18:267-271.
  6. Mauldin EA, Peters-Kennedy J. Integumentary system. In: Maxie MG Jubb, Kennedy,and Palmer’s Pathology of Domestic Animals. Vol 1. 6th ed. Philadelphia, PA: Elsevier Ltd. 2016:691-692.
  7. Roccabianca P, Rondena M, Paltrinieri S, Pocacqua V, Scarpa P, Faverzani S, et al. Multiple endocrine neoplasia type-I-like syndrome in two cats.  Vet Pathol. 2006; 43:345-352.
  8. Sharpe, SJ, Meadows, RL, Senter, DA, and Kuroki, K. Pathology in Practice. J Am Vet Med Assoc. 2014; 244:1265-7.
  9. Turek MM: Cutaneous paraneoplastic syndromes in dogs and cats: A review of the literature. Vet Dermatol. 2003; 14:279-96.


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