December 2017
U-F01 (NP)

Signalment (JPC #1807217):  A killer whale

HISTORY:  None provided

HISTOPATHOLOGIC DESCRIPTION:  Slide A.   Kidney:  Markedly expanding and replacing both the cortical and medullary interstitium, separating, surrounding, and replacing tubules, and to a lesser extent filling the renal pelvis are multifocal to coalescing random aggregates of numerous viable and degenerate neutrophils, fewer macrophages, lymphocytes, plasma cells, and variable amounts of eosinophilic cellular and karyorrhectic debris (necrosis) and fibrin which is occasionally surrounded by fibrosis.  These areas are often centered on numerous oval to round, 3-6 um diameter, pale-staining, thin-walled blastospores and blastoconidia arranged in short chains (pseudohyphae), and slender, 3-4 um wide, septate, parallel-walled hyphae.  Tubules within and adjacent to affected areas  are mildly ectatic, lined by attenuated epithelium, and are filled with sloughed epithelial cells, neutrophils, and necrotic cellular debris (cellular or granular casts).  Tubule epithelium is undergoing various stages of degeneration (epithelial hypertrophy with cytoplasmic pallor and vacuolation) and necrosis (shrunken, bright eosinophilic cells with pyknotic nuclei) and  cccasionally tubules are lined by epithelial cells with increased cytoplasmic basophilia, prominent nucleoli, and rare mitoses (regeneration).  Multifocally the urothelium in the renal pelvis is hyperplastic or eroded.  There are few variably sized aggregates of neutrophils and debris within the renal pelvis (pyelitis).

Slide B:  Kidney (PAS):  Numerous PAS positive yeast, pseudohyphae, and hyphae.

Slide C:  Kidney (Gridley):  Numerous argyrophilic yeast, pseudohyphae, and hyphae.

MORPHOLOGIC DIAGNOSIS:  Kidney:  Nephritis, tubulointerstitial, necrosuppurative, subacute, multifocal to coalescing, moderate, with pyelonephritis and numerous PAS positive and argyrophilic hyphae, pseudohyphae, and yeast, Killer whale (Orcinus orca).


CAUSE:  Candida spp.










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