JPC SYSTEMIC PATHOLOGY
DIGESTIVE SYSTEM
October 2018
D-M14 (NP)

Signalment (JPC #2558677):  9-month old female beagle

HISTORY:  Incidental necropsy finding in a beagle used in a toxicology study.

HISTOPATHOLOGIC DESCRIPTION:  Jejunum:  Multifocally replacing intestinal mucosa are several well-demarcated foci, up to 1.5 mm wide, of gastric mucosa composed of tightly packed tubular glands lined by cuboidal cells with basally positioned nuclei and apical, lightly eosinophilic, foamy cytoplasm (chief cells) or with round nuclei and abundant eosinophilic, granular cytoplasm (parietal cells).  Diffusely, remaining villi and crypts are lined by markedly increased numbers of goblet cells (goblet cell hyperplasia).

MORPHOLOGIC DIAGNOSIS:  Jejunum:  Heterotopic fundic gastric mucosa, multifocal, segmental, with diffuse goblet cell hyperplasia, beagle, canine.

CONDITION: Gastric heterotopy (choristoma)

GENERAL DISCUSSION:

PATHOGENESIS:

TYPICAL CLINICAL FINDINGS:

TYPICAL GROSS FINDINGS:

TYPICAL LIGHT MICROSCOPIC FINDINGS:

ADDITIONAL DIAGNOSTIC TESTS:

DIFFERENTIAL DIAGNOSIS:

Intestinal Masses:

COMPARATIVE PATHOLOGY:

REFERENCES:

  1. World Health Organization International Histological Classification of Tumors of Domestic Animals. Vol X. Second Series. Armed Forces Institute of Pathology; 2003:108-109.
  2. Iwata H, Arai C, Koike Y, et al. Heterotopic gastric mucosa of the small intestine in laboratory beagle dogs. Toxicol Pathol. 1990;18:373-379.
  3. Kusewitt D. Neoplasia and tumor biology. In: Zachary JF, McGavin MD, eds, Pathologic Basis of Veterinary Disease. 5th ed. St. Louis, MO: Elsevier; 2012: 291.
  4. Maitra A, Kumar V. Diseases of infancy and childhood.In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, PA: Saunders Elsevier; 2015: 267,473.
  5. Panigrahi D, Johnson AN, Wosu NJ. Adenocarcinoma arising from gastric heterotopia in the jejunal mucosa of a beagle dog. Vet Pathol. 1994;31:278-80,


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