Close Window

R-N13A - Ovarian adenocarcinoma - ovary, oviduct - chicken


Signalment:  2 year old female sex-link chicken


History:  Died after a two day history of listlessness. She had a history of laying rubber eggs with tissue/blood.


Histopathologic Description:
Ovary: Ovarian tissue is multifocally effaced by an unencapsulated, densely cellular, infiltrative neoplasm composed of nest of polygonal cells forming irregular tubules and acini on a moderate fibrovascular stroma. Neoplastic cells have indistinct cell boarders, moderate amount of eosinophilic cytoplasm that often contains multiple 2-5 um round, eosinophilic cytoplasmic granules. (visible in less aulolytic areas) Nuclei are irregularly round with finely stippled chromatin and indistinct nucleoli. Anisocytosis and anisokaryosis are moderate and mitosis is less than 1 per 40 X HPF. Multifocally within the neoplasm are large areas of amorphous, eosinophilic material (secretory product)


To view the Virtual Slide, click the image:  


Morphologic Diagnosis:   Ovary: Adenoarcinoma.


General Discussion:


Pathogenesis:


Typical Clinical Findings:


Typical Gross Findings:


Typical Light Microscopic Findings:
Ovarian adenocarcinoma


Oviduct adenocarcinoma


Additional Diagnostic Tests:


Differential Diagnosis:
Gross ovarian neoplasm:


Comparative Pathology:


References:

1. Kennedy PC, Cullen JM, Edwards JF, Goldschmidt MH, Larsen S, Munson L, Nielsen S. Histological classification of the tumors of the genital system of domestic animals. In: Schulman FY, eds. World Health Organization, Histological Classification of Tumors of Domestic Animals. Vol. 4. 2nd ed. Washington, DC: The Armed Forces Institute of Pathology, 1998: 24-28.

2. Reece RL. Other tumors of unknown etiology. In: Calnek BW, Barnes HJ, Beard CW, McDougald LR, Saif YM, eds. Diseases of Poultry. 11th ed. Ames, IA: Iowa State University Press; 2003: 542-547


Close Window